Internet-based Medical Data Rendering and Image Enhancement Using Webgl and Apache Server

Internet-based medical data visualization has wide applications in distributed medical collaborations and treatment. It can be achieved through volume rendering technique, which is a key method for medical image exploration and has been applied to the clinical medical fields such as disease diagnosis and image-guided interaction.In this project, we implement some medical data processing and optical mapping methods for web-based medical data visualization and image enhancement. The Web Graphics Library (WebGL) is used with JavaScript for rendering 3D graphics in a web browser. WebGL supports GPU based volume rendering which is an efficient tool for visual analysis of medical data, which involves vertex shaders and fragment shaders. The vertex shader provides space coordinates, and the fragment shader provides color.Network-based volume rendering is used to visualize data in a 3D form. An image processing method is implemented to transfer the 3D dataset into multiple slices of 2D image data and WebGL is employed to render 3D medical data in web browsers. Volume rendering is accomplished using the volume ray casting algorithm implemented with WebGL2. We collect new medical data and process them to fit the web-based rendering environment. The submitted work will explain the process of preparing and loading medical data suitable to be rendered. All the visualized data can be enhanced with the developed methods to emphasize the image feature of interest. We also add new control points for optical mapping and rendering medical data in a web browser in real-time. The software platform is running on Apache Web Server for network-based data visualization. The developed image enhancements and property control methods can improve medical data visualization on web browsers, which will be helpful for internet-based medical data analysis and exploration, as well as medical diagnosis and treatment.https://ir.library.illinoisstate.edu/ursit/1000/thumbnail.jp

Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?

Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a specialized cellular junction, known as the immunological synapse that stands as a pivotal determinant for effective cell killing. Extensive research has focused on the presynaptic side of the immunological synapse and elucidated the multiple functions of the CL actin cytoskeleton in synapse formation, organization, regulatory signaling, and lytic activity. In contrast, the postsynaptic (cancer cell) counterpart has remained relatively unexplored. Nevertheless, both indirect and direct evidence has begun to illuminate the significant and profound consequences of cytoskeletal changes within cancer cells on the outcome of the lytic immunological synapse. Here, we explore the understudied role of the cancer cell actin cytoskeleton in modulating the immune response within the immunological synapse. We shed light on the intricate interplay between actin dynamics and the evasion mechanisms employed by cancer cells, thus providing potential routes for future research and envisioning therapeutic interventions targeting the postsynaptic side of the immunological synapse in the realm of cancer immunotherapy. This review article highlights the importance of actin dynamics within the immunological synapse between cytotoxic lymphocytes and cancer cells focusing on the less-explored postsynaptic side of the synapse. It presents emerging evidence that actin dynamics in cancer cells can critically influence the outcome of cytotoxic lymphocyte interactions with cancer cells

Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

Objective To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years

Methodology for the management of discrete event simulation projects based on PMBOK ®: Action research in a high-tech company

© 2018 IEEE Discrete Event Simulation (DES) is a powerful tool for decision making. It has been widely used in different application fields. There are many works investigating the simulation modeling process, but little is found in the literature that considers how to manage a DES project. In this respect, this paper has the objective of proposing a specific methodology for the management of DES projects based on PMBOK. This was considered to be the methodology that most fits with the requirements of DES. In order to test the approach, PMBOK was applied in a real simulation project. The methodology was then evaluated by the simulation analysts who provided their feedback on the study

Exports and Productivity: Comparable Evidence for 14 Countries

We use comparable micro level panel data for 14 countries and a set of identically specified empirical models to investigate the relationship between exports and productivity. Our overall results are in line with the big picture that is by now familiar from the literature: Exporters are more productive than non-exporters when observed and unobserved heterogeneity are controlled for, and these exporter productivity premia tend to increase with the share of exports in total sales; there is strong evidence in favour of self-selection of more productive firms into export markets, but nearly no evidence in favour of the learning-by-exporting hypothesis. We document that the exporter premia differ considerably across countries in identically specified empirical models. In a meta-analysis of our results we find that countries that are more open and have more effective government report higher productivity premia. However, the level of development per se does not appear to be an explanation for the observed cross-country differences.exports; productivity; micro data; international comparison

Mapeamento de personalidade de alunos ingressantes e concluintes do curso de Engenharia de Produção da Universidade Federal de Itajubá

Considering that the market tends to be competitive in the search for better technologies, tools and methodologies to reach their goals, companies have been looking for professionals with profile compatible with the job opportunity of the organization. For this, recruiters can use personality tests as a complement in the selection process, one of these methods is Big Five. Thus, the purpose of this paper was to identify personality traits of students in a course and to compare the traits of incoming students with graduating students. This work was conducted by means of a Survey, in which the necessary data for the research can be obtained. As a result, there was a similarity between the personality traits of incoming students and graduating students. In addition, in terms of extroversion, both have a high level of adherence to this trait, but when it comes to opening new experiences, new entrants are more conservative than seniors.Teniendo en cuenta que el mercado tiende a ser competitivo en la búsqueda de mejores tecnologías, herramientas y metodologías para alcanzar sus objetivos, las empresas han estado buscando profesionales con un perfil compatible con la oportunidad de trabajo de la organización. Para esto, los reclutadores pueden usar pruebas de personalidad como complemento en el proceso de selección, uno de estos métodos es Big Five. Por lo tanto, el propósito de este documento era identificar los rasgos de personalidad de los estudiantes de un curso y comparar los rasgos de los estudiantes entrantes con los estudiantes graduados. Este trabajo se realizó mediante una encuesta o Encuesta, en la que se pueden obtener los datos necesarios para la investigación. Como resultado, hubo una similitud entre los rasgos de personalidad de los estudiantes entrantes y los estudiantes graduados. Además, en términos de extroversión, ambos tienen un alto nivel de adhesión a este rasgo, pero cuando se trata de abrir nuevas experiencias, los nuevos participantes son más conservadores que los adultos mayores.Considerando que o mercado tende a ser competitivo no sentido de buscar melhores tecnologias, ferramentas e metodologias para alcançar seus objetivos, as empresas tem buscado por profissionais com perfil compatível com a oportunidade de trabalho da organização. Para isso, recrutadores podem utilizar de testes de personalidade como um complemento no processo seletivo, um desses métodos é Big Five. Dessa forma, o objetivo deste artigo foi identificar traços de personalidades de alunos de uma curso e comparar os traços dos alunos ingressantes com os alunos concluintes. Este trabalho foi conduzido por meio de um levantamento ou survey, em que pode-se obter os dados necessários para a pesquisa. Como resultado observou-se semelhança entre os traços de personalidade dos alunos ingressantes e de alunos concluintes. Além disso, no quesito extroversão ambos apresentam alto nível de aderência a esse traço mas, no quesito abertura de novas experiências, os ingressantes são mais conservadores que os concluintes

Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika.info:eu-repo/semantics/publishedVersio

Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika

Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates

<div><h3>Background</h3><p>Otitis media (OM) is a leading cause of health care visits and drugs prescription. Its complications and sequelae are important causes of preventable hearing loss, particularly in developing countries. Within the Global Burden of Diseases, Injuries, and Risk Factors Study, for the year 2005 we estimated the incidence of acute OM, chronic suppurative OM, and related hearing loss and mortality for all ages and the 21 WHO regional areas.</p> <h3>Methods</h3><p>We identified risk factors, complications and sequelae of OM. We carried out an extensive literature review (Medline, Embase, Lilacs and Wholis) which lead to the selection of 114 papers comprising relevant data. Data were available from 15 of the 21 WHO regions. To estimate incidence and prevalence for all countries we adopted a two stage approach based on risk factors formulas and regression modelling.</p> <h3>Results</h3><p>Acute OM incidence rate is 10.85% i.e. 709million cases each year with 51% of these occurring in under-fives. Chronic suppurative OM incidence rate is 4.76‰ i.e. 31million cases, with 22.6% of cases occurring annually in under-fives. OM-related hearing impairment has a prevalence of 30.82 per ten-thousand. Each year 21thousand people die due to complications of OM.</p> <h3>Conclusions</h3><p>Our study is the first attempt to systematically review the available information and provide global estimates for OM and related conditions. The overall burden deriving from AOM, CSOM and their sequelae is considerable, particularly in the first five years of life and in the poorest countries. The findings call for incorporating OM-focused action within preventive and case management strategies, with emphasis on the more affected.</p> </div